Munguva yedenda, vanachiremba vari kushandisa transfused monoclonal antibodies ( laboratory-yakagadzirwa masoja ekudzivirira chirwere) kubatsira varwere kurwisa hutachiona hweCOVID-19. Iye zvino UC Davis vatsvakurudzi vari kuedza kugadzira monoclonal antibodies inogona kubatsira kurwisa kurwadziwa kusingaperi. Chinangwa ndechekugadzira isina-kupindwa muropa marwadzo pamwedzi inogona kutsiva opioid.
Chirongwa ichi chinotungamirwa naVladimir Yarov-Yarovoi naJames Trimmer, mapurofesa muDhipatimendi rePhysiology uye Biology yeMembrane paYunivhesiti yeCalifornia, Davis Chikoro cheMishonga. Vakaunganidza boka rakasiyana-siyana raisanganisira vazhinji vevaongorori vakafanana vaiedza kushandura huturu hwe tarantula kuva painkillers.
Pakutanga gore rino, Yarov-Yarovoy naTrimmer vakagamuchira rubatsiro rwemadhora miriyoni imwe nemazana mashanu kubva kuchirongwa cheNational Institutes of Health's HEAL, inova kuyedza kukurumidza kukurumidza mhinduro dzesainzi kuti dzive nedambudziko reopioid yenyika.
Nekuda kwekurwadziwa kusingaperi, vanhu vanogona kupindwa muropa neopioid. Centers for Disease Control's National Center for Health Statistics inofungidzira kuti kuchave ne107,622 kufa kwezvinodhaka zvakanyanya muUnited States muna 2021, vangangoita gumi neshanu muzana kupfuura vakafa vanosvika makumi mapfumbamwe nemakumi matanhatu neshanu muna 2020.
"Kubudirira kuchangobva kuitika mukugadzirwa kwemaitiro uye computational biology - kushandiswa kwemakombiyuta kunzwisisa uye kuenzanisira maitiro ehupenyu hwehupenyu - kwakaisa hwaro hwekushandiswa kwemaitiro matsva ekugadzira masoja ekudzivirira zvirwere semushonga wemishonga yekurapa marwadzo asingagumi," akadaro Yarov. Yarovoy, mutambi mukuru wemubairo weSai.
"Monoclonal antibodies inzvimbo iri kukurumidza kukura yeindasitiri yemishonga uye inopa mabhenefiti akawanda pamusoro pemishonga diki yemamorekuru," akadaro Trimmer. Small molecule mishonga mishonga inopinda nyore nyore mumasero. Dzinoshandiswa zvakanyanya mukurapa.
Kwemakore, Trimmer's lab yakagadzira zviuru zvemamonoclonal antibodies kune zvakasiyana siyana zvezvinangwa, asi uku ndiko kuedza kwekutanga kugadzira antibody yakagadzirirwa kubvisa marwadzo.
Kunyangwe ichitaridzika ramangwana, iyo US Food and Drug Administration yakabvumidza monoclonal antibodies ekurapa nekudzivirira migraine. Mishonga mitsva inoshanda paprotein yakabatana nemigraine inonzi calcitonin gene-related peptide.
Iyo UC Davis purojekiti ine chinangwa chakasiyana - chaiyo ion nzira mumasero etsinga anonzi voltage-gated sodium chiteshi. Idzi nzira dzakafanana ne "pores" pamasero etsinga.
“Masero etsinga ndiwo anoita basa rekufambisa zviratidzo zvekurwadziwa mumuviri. Inogona-gated sodium ion channels mumasero etsinga ndiwo makuru ekuparadzira marwadzo, "anotsanangura kudaro Yarov-Yarovoy. "Chinangwa chedu ndechekugadzira masoja ekudzivirira chirwere anosunga kune idzi nzvimbo dzekutapurirana pachikamu chemolecular, inhibit basa ravo uye kudzivirira kutapurirana kwezviratidzo zvinorwadza."
Vatsvakurudzi vakatarisa pamatatu chaiwo e sodium ane chokuita nemarwadzo: NaV1.7, NaV1.8, uye NaV1.9.
Chinangwa chavo ndechekugadzira masoja ekudzivirira chirwere anoenderana nematanho aya, sekiyi inokiinura. Iyi nzira yakanangwa yakagadzirirwa kudzivirira kutapurirana kwezviratidzo zvinorwadza kuburikidza nemugero pasina kupindirana nemamwe masaini anofambiswa kuburikidza nemasero etsinga.
Dambudziko nderekuti magadzirirwo ematanho matatu avari kuedza kuvhara akaomarara.
Kugadzirisa dambudziko iri, vanotendeukira kuRosetta neAlphaFold zvirongwa. NeRosetta, vatsvakurudzi vari kugadzira maitiro akaoma eprotein uye kuongorora kuti ndeapi mamodheru anonyatsokodzera NaV1.7, NaV1.8, uye NaV1.9 neural channels. NeAlphaFold, vaongorori vanogona kuyedza vakazvimirira mapuroteni akagadzirwa naRosetta.
Pavakangoona mapuroteni mashoma anovimbisa, vakagadzira masoja ekudzivirira chirwere anogona kuzoongororwa paneural tishu akagadzirwa mulabhu. Miedzo yevanhu ichatora makore.
Asi vatsvakurudzi vari kufara pamusoro pekugona kweiyi nzira itsva. Non-steroidal anti-inflammatory drugs (NSAIDs), yakadai seibuprofen neacetaminophen, inofanira kutorwa kakawanda pazuva kuti ibvise marwadzo. Opioid painkillers inowanzotorwa zuva nezuva uye inotakura njodzi yekupindwa muropa.
Zvisinei, masoja ekudzivirira chirwere anonzi monoclonal anogona kutenderera muropa kweanopfuura mwedzi asati aputswa nemuviri. Vatsvakurudzi vaitarisira kuti varwere vazvipire yega analgesic monoclonal antibody kamwe chete pamwedzi.
"Kune varwere vane kurwadziwa kusingaperi, izvi ndizvo chaizvo zvaunoda," akadaro Yarov-Yarovoy. “Vanonzwa kurwadziwa kwete kwemazuva, asi kwemavhiki nemwedzi. Zvinotarisirwa kuti masoja ekudzivirira chirwere anotenderera achakwanisa kupa zororo remarwadzo rinogara kwemavhiki akati wandei. "
Dzimwe nhengo dzechikwata dzinosanganisira Bruno Correia weEPFL, Steven Waxman waYale, EicOsis' William Schmidt naHeike Wolf, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, uye Robert Stewart weUC Davis.
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Nguva yekutumira: Sep-29-2022